Research in our lab ranges from developing novel mass spectrometric method development to understanding mechanistic nuances of cell signaling. Accordingly, we have an extremely diverse group of scientists who bring orthogonal expertise to the lab. Together, we address the questions at hand in a collaborative manner.
Assistant Professor of Cell Biology
PhD Indian Institute of Science (2013)
Fellow of the 1851 Royal Commission, Oxford University (2013)
Initially trained as a chemist, I was introduced to the world of biology through the aquatic route, where my goal was to uncover the molecular diversity present in the venoms of marine cone snails and understand how it impairs the functions of key ion channels and transporters. This introduced and made me fascinated about the world of membrane proteins.
I subsequently moved to the University of Oxford as a Fellow of the 1851 Royal Commission. Here, my research led to a transformative advancement that enabled top-down mass spectrometric (MS) analysis of membrane protein-lipid complexes. Application of this approach yielded atomistic understanding of how lipids act as a key signaling molecule to regulate structural and functional organization of membrane proteins.
In the Fall of 2018, I crossed the pond to start my own lab in Yale. Combining native mass spectrometry with an array of orthogonal experimental and computational approaches, our lab is focused on developing platforms that enable quantitative analysis of macromolecular protein complexes directly from the cellular environment. Applying this, the lab aims to understand how spatiotemporal organization of membrane protein interactomes regulate cellular physiology.
When I am not in the lab, you shall me find me in some hiking trail.
Associate Research Scientist
PhD Polish Academy of Sciences (2014)
I am biochemist with a PhD from the Institute of Biochemistry and Biophysics Polish Academy of Sciences in Warsaw. I am interested in the role of protein-protein interaction at the cellular membrane. During my postdocs at University of California, San Diego and Cornell University, I was investigating the role of phosphorylation in activation of plant immune response. In the Gupta lab I am using native mass spectrometry to examine the complexes of membrane-associated proteins and their role Parkinson's. When not in the lab, I run for the beers!
Post Doctoral Researcher
PhD National Centre for Biological Sciences (2019)
I am developing a novel platform that enables direct detection of membrane protein from the lipid bilayer. Using this approach, I am investigating how hierarchical organization of the SNARE and SNARE associated proteins in synaptic vesicle regulate fast neurotransmitter release.
I did my PhD in 2019 from National Centre for Biological Sciences, TIFR, Bangalore under the supervision of Prof. Raghu Padinjat. During this period, I have performed the biochemical analysis of Phospholipase D in lipid homeostasis in Drosophila melanogaster.
I enjoy playing football when I'm not immersed in experiments.
I am a graduate student interested in method development of nativeMS to study challenging biological problems. During my PhD, I aim to develop a top-down nativeMS platform for analysis of membrane protein complexes directly from their native membrane vesicles. This will effectively yield a “snapshot” of membrane protein assemblies in their most physiologically relevant forms. It is my hope that development of this transformative technology will expand our understanding of MP interactomes in a wide variety of biological contexts. When I’m not in lab, you can find me exploring the New England area in search of the perfect cup of coffee, cooking up new recipes, or browsing the local craft store for my latest DIY project!
I studied biology and biochemistry at Villanova University, and conducted a post-baccalaureate fellowship at the NIH. Here, I studied protein and membrane trafficking events at the cellular level. I now want to explore cellular cargo transport in refined, granular detail. Specifically, I am using innovative new technologies to decipher the intra-membrane organization of a troublesome oncogenic protein, hoping to decipher how the oily environment of the plasma membrane alters its behavior and suite of interaction partners. When I'm not in the lab, I can be found trail running and fishing.
I studied biochemistry at UCLA before joining Yale as a graduate student in 2020. In my undergrad lab, I worked on the mechanism of sortase, a bacterial pilin polymerase. My current projects include a joint advisorship between Dr. Bhattacharyya and Dr. Gupta to investigate the oligomerization of Bruton’s Tyrosine Kinase (BtK) on the membrane and optimize structural and functional assays in the context of the native membrane. My free time is spent reading, playing tennis, or hiking around New Haven.
Post-Graduate Research Associate
Lipidomics signal processing and automation is my concentration in the Gupta lab. My specific focus is to understand how inter-organelle lipid crosstalk is regulated and how that is perturbed in Parkinson's disease.
Improved efficiency, extracting more information from data, and precise measurements are the things that span my interests. I code, perform experiments, design small instruments, write grants, and interface with people at diverse levels.
Longer term goals are to use medical ethnography, device design, and process innovation to help other humans improve their own lives, including limited resource situations. In my spare time, I enjoy gardening, hiking, and cooking
Post-Graduate Research Associate
Msc University of Oxford(2016)
Trained as a social anthropologist, my passion for science led me to the Gupta lab where I have followed the lesser known narrative of the chemical interplay between membrane proteins and lipids, and how this regulates our cellular physiology. I have worked on the development of a novel mass spectrometry based investigative platform for studying lipids and aim to use this platform to address pertinent biological questions. Outside the lab, I am often found taking a hike in my natural habitat.