The GupTa Lab

The Gupta lab develops and applies quantitative, multidisciplinary approaches to address fundamental and disease-related questions in membrane biology.  From neuronal signaling to immune response, the macromolecular organization of membrane proteins and lipids at the cell membrane governs a wide range of cellular signaling pathways. Consequently, their impairments are causal towards a host of pathological conditions, and membrane proteins are targets of more than 60% of marketed drugs. We, at the Gupta Lab, take a multidisciplinary approach to develop novel quantitative tools to capture these organizational states and apply them to specific problems pertaining to human health and disease. To achieve this, we employ a range of orthogonal tools, including native mass spectrometry, lipidomics, proteomics, single-molecule imaging, electron microscopy, and synthetic chemistry, and combine these with various cell-based and in vitro biochemical assays.

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We achieve these outstanding goals with a passionate, scientifically diverse group of researchers, where lab members bring highly complementary scientific expertise. This ranges from biochemists to biophysicists to mass spectrometrists to synthetic chemists, and even anthropologists. We work collaboratively to achieve our overarching scientific goal while valuing our diverse opinions and learning from one another. Head to the “OUR TEAM” section to know more about us, and the “RESEARCH” and “PUBLICATIONS” sections to know more about our work.

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Yale University is an Affirmative Action/Equal Opportunity employer.